Dr. Jonathan Coulter
Dr Coulter is a Senior Lecturer, working within the Nanomedicine and Biotherapeutics research group at the School of Pharmacy, Queen’s University Belfast. His research has always had a focus on developing strategies to overcome treatment resistance in cancer, with a specific focus on radiotherapy. His work has spanned approaches that include the use of suicide gene therapy and more recently exploiting the unique physical properties of high atomic number nanoparticles as radiosensitisers. Recent iterations have been developed as biologically active formulations, designed to overcome tumour microenvironment properties which are known to confer treatment resistance, in addition to the core particle acting as a radiation dose modifier. This presentation aims to outline some of the successes we have experienced in this space while looking to spark discussion around the key challenges that have limited clinical translation to date.
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